antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury

objective(s): to evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion–detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (ir) injury. materials and methods: eighteen female wistar albino rats were used in control, ir, and ir+edosteine (ir-e) groups, (n=6 in each). the ir-e group received the erdosteine for seven days before the induction of torsion/retorsion, (10 mg/kg/days). the ir and ir-e groups were exposed to right unilateral adnexal torsion for 3 hr. three hours later, re-laparotomy was performed, and the right ovaries were surgically excised. oxidant and antioxidants levels were determined in serum. the ovarian tissue samples were received and fixed with 10% neutral buffered formalin. the sections were stained with h&e;, anti-pcna, and tunel. results: the ir group were showed severe acute inflammation, polynuclear leukocytes and macrophages, stromal oedema and haemorrhage. treatment with erdosteine in rats significantly retained degenerative changes in the ovarypcna (+) cell numbers were significantly decreased in the ir and ir-e groups unlike the control group. however, its numbers were significantly increased in the ir-e group unlike the ir group. tunel (+) cell numbers were significantly increased in the ir group unlike the control and the ir-e groups. in erdosteine treated group, tunel (+) cells were detected significantly less than the ir group (p<0.05). conclusion: in conclusion, erdosteine maybe a protective agent for ovarian damage and decreasing lipid peroxidation products and leukocytes aggregation after adnexal torsion in animals.